scalp treatments for dandruff, seborrheic dermatitis, itchy scalp
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ZincPlex Results:

Take  A Look At These Hair Photos:

 

Dirt, Bacteria & Build Up On This Hair Resulted In Scalp Acne, Itchy Scalp and Scalp Flaking! See below for results after 30 Days!

 

 

After 30 Days of Zincplex You Can See That The Dark Area At The Root Of The Hair Shows The Hair Is Now Clean! The Scalp Itching , Flaking and Scalp Acne All Went Away!

 

 

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How does Zinc PCa Work For Scalp Acne and Scalp Bumps

 

 

 

What is zinc pca?

Zinc is one of the essential trace elements for any living body.1 Fish and shellfish are naturally rich in zinc. Zinc deficiency in humans is unlikely to occur with a balanced diet. However, an unbalanced diet is known to cause dysgeusia, reproductive dysfunction, skin roughness, hair loss and so on. In elderly people, similar unbalanced diets can lead to a compromised immune function.2

In the field of cosmetic and toiletry products, zinc is known to form nonvolatile salts with fatty acids and other substances, and exert antibacterial activity (scalp acne, body acne, facial acne, folliculitis are all caused by bacteria).

Sebum inhibiting activity and Dht Prevention

Dihydrotestosterone (DHT), a product of testosterone and responsible for hair loss and thinning in both men and women is produced in the body (the sebum gland) by the action of the enzyme 5 a-reductase. This DHT hormone stimulates the sebaceous (oil) glands to produce and secrete excess sebum at a higher rate in both men and women. Zinc inhibits 5 a-reductase activity.4,5  The inhibition of the DHT is what is believed to be the cornerstone of preventing Hair Loss. Zinc pca proved to prevent the the formation of dht by reducing the metabolic action required by the body to produce DHT from testosterone.

Scalp Odor, Hair Odor and Body Odor

If zinc forms salts with short-chain fatty acids that cause body odorr, the characteristic odorr disappears as shown in Figure 3. In this connection, zinc PCA, which is a zinc compound, is expected to suppress body odor, scalp odor, skin odor, hair odor by forming nonvolatile salts with short-chain fatty acids in the skin. It is one of the few natural based ingredients on the market today that can do this.
 


What is zinc PCA?
As described above, zinc inhibits sebum secretion, blocks dht and helps with body odor. However, the solubility of zinc salts is usually low, making it difficult to add zinc compounds to cosmetics, and difficult for the effects of zinc compounds to manifest. We paid close attention to pyrrolidone carboxylic acid (PCA), which is an organic acid, as a counter for the formation of zinc salts, and evaluated its functions.

PCA is the predominant component of NMF (Natural Moisturizing Factor) and is known to play important roles. PCA originates from glutamic acid abundantly contained in the living body. Glutamic acid, which is biosynthesised by hydrolysis of filaggrin (a protein) during the course of skin keratinisation, is hydrolysed and cyclised with skin enzymes (g-glutamyl-AA synthetase and g-glutamyl cyclotransferase),7 to yield PCA. Usually, PCA is found in the skin in the form of salts (Na salt, K salt, etc.) and it is abundantly contained in NMF.8 PCA, assuming the form of salt, is known to serve as a moisturiser which keeps the skin soft and to exert excellent conditioning effects on the hair.

Characteristics of Zinc Pca

The following effects of zinc PCA have been confirmed in the study:

* Reduction of unwanted sebum.

* Inhibition of activator protein-1 production.

* In addition, reduction effects on microorganisms were measured including bacteria, fungus and protozoa.


Test Subject Procedure Shows Significant Reduction in Sebum Production
The subjects (people in the experiment) were asked to apply 1% zinc PCA aqueous solution, 1% zinc gluconate and water to the one determined side of their face. This was done morning and then again in the evening, for a total period of 4 weeks (1 month). Secreted sebum (oils) was measured by "sebumeter" measurements (SM 810 PC, Couage and Kazaka, Electronic Gm bH meter) and the measurement on the treated skin after three hours and four weeks was expressed as a ration of the initial value (before the treatment). All the subjects were required to complete a 30-minute acclimation period in the environmental chamber (22.1°C, 39.9% relative humidity), This is where the oil (sebum) final measurements were then taken of the subjects.

Results of Zinc PCA Application To Oily Skin and Hair
By application of zinc PCA, statistically (large) significant decrease of the sebum content from the initial value was observed.

Inhibition of Activator Protein-1 and Collagen

Collagen, which is indispensable for keeping the skin tense and to prevent wrinkle formation, is degraded by collagenase (an enzyme that degrades collagen). Therefore, to suppress wrinkle formation, it is necessary to suppress collagenase production.


Mechanism of collagen degradation and wrinkle formation

Procedure
Zinc PCA was added to human fibroblasts and the cells were irradiated with UVA. After the irradiation, the amount of c-FOS (a component of AP-1) was determined.

Calculation Method For Results
A: zinc PCA (+), UVA irradiation (+) (add)  B: zinc PCA (-), UVA irradiation (+) (add) C: zinc PCA (-), UVA irradiation (-) c-FOS Production inhibition (%) = {1-(A-C)/(B-C)} x 10.


Minimum Inhibitory Concentration (MIC)  and Zinc PCA

Procedure
Agar (mid size) medium containing ZINCPCA at varying or multi dimensional concentrations was made and then they were placed on culture plates. Each (o the different Micro organism suspended in culture media was placed and seeded on the agar plate. After an incubation period , the minimum inhibitory concentration (MIC) was then found. MIC is explained as the very smallest concentration on microorganisms and still there is no growth visible to the eye. (Agar plate dilution method) *The concentration indicates that of zinc PCA itself.
 

Formulation

Zinc PCA is expected to be useful not only in ordinary skin care but also to exert the above-mentioned effects more markedly if combined with shampoos, conditioners, and body and facial cleansers.

Augmentation of its effects is expected if the shampoos or conditioners containing this substance are used in combination with other antibacterial agents or anti-acne products (containing zinc pyrithione, piroctone olamine and so on). If combined with substances known to stimulate hair growth (amino acids, blood flow promoting agents (PCA, vitamin E and other various extracts), more efficacy in stimulating hair growth is expected. As stated above, the effect in suppressing AP-1, etc is expected to be augmented if this substance is combined with elements having an anti-oxidative activity (known as anti wrinkle agents).


Conclusion of Zinc PCA Testing

It has been shown that zinc PCA exerts not only the effects expected from a Zn salt (sebum suppression, body odor reduction, etc.) but also some previously unknown effects (AP-1 inhibition effect, etc). Humans tend to be anxious about oil-producing and odorous areas of the body, even as they get older, and they are highly concerned about skin wrinkles, which increase with ageing. Zinc PCA is expected to be used extensively not only as a means of suppressing sebum and body odor, but also as an ingredient for anti-ageing products. Flaking and itching behind conditions like Seborrheic Dermatitis and Dandruff are believed to be caused by fungus of the malassezia furfur family. The anti bacterial and anti fungal characteristics of Zinc Pca lend itself to symptom reduction for both dandruff and seborrheic dermatitis.

This information is furnished without warranty, expressed or implied, except that it is accurate to the best knowledge of AJINOMOTO CO. INC. It relates only to the specific material designated herein, and does not relate to use in combination with any other material or in any process. AJINOMOTO CO. INC. assumes no legal responsibility for use of or reliance upon this.

 

 

 

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